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RNA pocket database for drug design



The RNA-protein structural information especially pocket-based interaction information is important for drug discovery targeting cancer or other diseases. Although some RNA-protein complex sequence, structure or drug databases have been developed, the databases cannot be directly used in the drug study. Therefore, a pocket-based interaction database is needed for the RNA-protein interaction mechanism understanding at the molecular level.

This database contains sequence and structure of RNA-protein complex, binding sites and pocket topology information(including volume, area, shape similarity score, effective radius, centroid, and the secondary structural elements the pocket located). It is developed to reveal RNA-protein recognition principles for RNA-related drug development or medical applications.

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Zhao Group at Central China Normal University